The role of RBC oxidative stress in sickle cell disease: from the molecular basis to pathologic implications
Q Wang, R Zennadi - Antioxidants, 2021 - mdpi.com
Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …
Synergistic integration of laboratory and numerical approaches in studies of the biomechanics of diseased red blood cells
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease
Erythrophagocytosis occurring in the spleen is a critical process for removing senescent and
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …
Circulating cell clusters aggravate the hemorheological abnormalities in COVID-19
Microthrombi and circulating cell clusters are common microscopic findings in patients with
coronavirus disease 2019 (COVID-19) at different stages in the disease course, implying …
coronavirus disease 2019 (COVID-19) at different stages in the disease course, implying …
Quantifying shear-induced deformation and detachment of individual adherent sickle red blood cells
Vaso-occlusive crisis, a common painful complication of sickle cell disease, is a complex
process triggered by intercellular adhesive interactions among blood cells and the …
process triggered by intercellular adhesive interactions among blood cells and the …
A computational study of fibrinogen-induced alteration in microvascular blood flow in COVID-19
Patients infected with COVID-19 may experience significant and long-lasting changes in the
mechanical and rheological properties of their blood cells, leading to microvascular …
mechanical and rheological properties of their blood cells, leading to microvascular …
Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies
Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle
hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte …
hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte …
Modeling biomembranes and red blood cells by coarse-grained particle methods
In this work, the previously developed coarse-grained (CG) particle models for
biomembranes and red blood cells (RBCs) are reviewed, and the advantages of the CG …
biomembranes and red blood cells (RBCs) are reviewed, and the advantages of the CG …
[HTML][HTML] Accompanying Hemoglobin Polymerization in Red Blood Cells in Patients with Sickle Cell Disease Using Fluorescence Lifetime Imaging
FA Borges da Silva, JB Florindo, AC Mattos… - International Journal of …, 2024 - mdpi.com
In recent studies, it has been shown that fluorescence lifetime imaging (FLIM) may reveal
intracellular structural details in unstained cytological preparations that are not revealed by …
intracellular structural details in unstained cytological preparations that are not revealed by …
[HTML][HTML] MEK1/2 as a therapeutic target in sickle cell disease
R Zennadi - International journal of blood research and disorders, 2019 - ncbi.nlm.nih.gov
Identification of novel therapeutic targets has improved diagnostics and treatment of many
diseases. Many innovative treatment strategies have been developed based on the newly …
diseases. Many innovative treatment strategies have been developed based on the newly …