Ten putative contributors to the obesity epidemic

EJ McAllister, NV Dhurandhar, SW Keith… - Critical reviews in …, 2009 - Taylor & Francis
The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Antipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systematic critical reappraisal

M Alvarez-Jimenez, C Gonzalez-Blanch… - CNS drugs, 2008 - Springer
Antipsychotic-induced weight gain is an important issue in the treatment of psychotic
illnesses, and affects 80% of individuals being treated with antipsychotic drugs. However …

Almost all antipsychotics result in weight gain: a meta-analysis

M Bak, A Fransen, J Janssen, J van Os, M Drukker - PloS one, 2014 - journals.plos.org
Introduction Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses
generally are restricted to second generation antipsychotics (SGA) and do not stratify for …

Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents

CU Correll, P Manu, V Olshanskiy, B Napolitano… - Jama, 2009 - jamanetwork.com
Context Cardiometabolic effects of second-generation antipsychotic medications are
concerning but have not been sufficiently studied in pediatric and adolescent patients naive …

Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study

CU Correll, DG Robinson, NR Schooler… - JAMA …, 2014 - jamanetwork.com
Importance The fact that individuals with schizophrenia have high cardiovascular morbidity
and mortality is well established. However, risk status and moderators or mediators in the …

Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity

N Ferri, P Siegl, A Corsini, J Herrmann… - Pharmacology & …, 2013 - Elsevier
Cardiovascular toxicity remains a major cause of concern during preclinical and clinical
development as well as contributing to post-approval withdrawal of medicines. This issue is …

Metabolic syndrome with the atypical antipsychotics

P Pramyothin, L Khaodhiar - Current Opinion in Endocrinology …, 2010 - journals.lww.com
Metabolic syndrome with the atypical antipsychotics : Current Opinion in Endocrinology,
Diabetes and Obesity Metabolic syndrome with the atypical antipsychotics : Current Opinion in …

Atypical antipsychotic-induced weight gain: insights into mechanisms of action

JL Roerig, KJ Steffen, JE Mitchell - CNS drugs, 2011 - Springer
Prescriptions for second-generation antipsychotics (SGAs) have surpassed those for first-
generation agents in the treatment of schizophrenia and bipolar disorder. While SGAs have …

Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis

NA Crossley, M Constante, P McGuire… - The British Journal of …, 2010 - cambridge.org
BackgroundThere is an ongoing debate about the use of atypical antipsychotics as a first-
line treatment for first-episode psychosis. AimsTo examine the evidence base for this …

Potential mechanisms of atypical antipsychotic-induced metabolic derangement: clues for understanding obesity and novel drug design

R Coccurello, A Moles - Pharmacology & therapeutics, 2010 - Elsevier
Beside the therapeutic improvement over first-generation antipsychotics, the fact that
prescription of atypical agents is also associated to the emergence of severe metabolic …