Highly active antiretroviral therapy (HAART) is very effective in suppressing HIV-1 replication
and restoring immune functions in HIV-infected individuals. However, it fails to eradicate the …

As the HIV-1 epidemic enters its fourth decade, HIV-1 associated neurological disorders
(HAND) continue to be a major concern in the infected population, despite the widespread …

ABSTRACT SARS-CoV-2, the etiological agent of COVID-19, is characterized by a delay in
type I interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production …

Defining the virus–host interactions responsible for HIV-1 transmission, including the
phenotypic requirements of viruses capable of establishing de novo infections, could be …

The interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA
intermediates. We show that IFI16 restricts HIV-1 independently of immune sensing by …

Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot
be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is …

SUMMARY A major impediment for HIV cure is the ability of the virus to integrate its genome
in the form of replication-competent proviral DNA into the cellular genome of the host and …

The Tat proteins of HIV-1 and simian immunodeficiency virus (SIV) are essential for
activating viral transcription. In addition, Tat stimulates nuclear factor κB (NF-κB) signaling …

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional
silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi …

In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …