Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression
and substance abuse. Twin studies have shown that anxiety disorders are moderately …

Objective We systematically review the literature on social epigenetics, examining how
empirical research to date has conceptualized and operationalized social determinants of …

MRI has enhanced our capacity to understand variations in brain structure and function
conferred by the genome. We identified 60 studies that report associations between DNA …

Early life stress in humans (ie maltreatment, violence exposure, loss of a loved one) and in
rodents (ie disrupted attachment or nesting, electric shock, restraint, predator odor) occurs …

DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in
development, genomic imprinting, X inactivation, chromosome stability, gene expression …

Background The BDNF gene codes for brain-derived neurotrophic factor, a growth factor
involved in neural development, cell differentiation, and synaptic plasticity. Present in both …

Certain individuals are more susceptible to stress and trauma, as well as the physical and
mental health consequences following such exposure, including risk for post-traumatic …

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been
postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and …