The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

On the 100 th anniversary of Alzheimer's lecture describing the clinicopathological entity
which bears his eponym, this article reviews the major areas of progress in our …

We report duplication of the APP locus on chromosome 21 in five families with autosomal
dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy …

In patients with Alzheimer's disease, amyloid fibrils that are aggregates of A4 protein
subunits are deposited in the brain. A similar process occurs at an earlier age in persons …

The cloning of APP and genetic analysis of families with Alzheimer's disease were both
reported in 1987 and much present work on the disease is based upon the foundations laid …

Membrane and cytoskeletal structures are known targets of oxidative injury. Brains from
patients with Alzheimer's disease have cytoskeletal abnormalities and platelet and possible …

We report identification of a novel genetic locus (GLC1P) for normal tension glaucoma
(NTG) on chromosome 12q14 using linkage studies of an African-American pedigree …

The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

Watson‐Crick base‐pair changes, or single‐nucleotide variants (SNV), have long been
known as a source of mutations. However, the extent to which DNA structural variation …

Down syndrome, the phenotypic expression of human trisomy 21, is presumed to result from
a 1.5-fold increase in the expression of the genes on human chromosome 21. As an …