The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Engineered in vitro tumor model recapitulates molecular signatures of invasion in glioblastoma

LJ Smith, A Skirzynska, AA Chin, AE Arnold… - ACS Materials …, 2023 - ACS Publications
Glioblastoma stem cells (GSCs) play an important role in the invasive nature of glioblastoma
(GBM); yet, the mechanisms driving this behavior are poorly understood. To recapitulate …

Modifications of plasma membrane organization in cancer cells for targeted therapy

A Choromańska, A Chwiłkowska, J Kulbacka… - Molecules, 2021 - mdpi.com
Modifications of the composition or organization of the cancer cell membrane seem to be a
promising targeted therapy. This approach can significantly enhance drug uptake or …

Breast cancer cells in microgravity: new aspects for cancer research

MZ Nassef, D Melnik, S Kopp, J Sahana… - International Journal of …, 2020 - mdpi.com
Breast cancer is the leading cause of cancer death in females. The incidence has risen
dramatically during recent decades. Dismissed as an “unsolved problem of the last century” …

Fighting thyroid cancer with microgravity research

M Krüger, D Melnik, S Kopp, C Buken… - International Journal of …, 2019 - mdpi.com
Microgravity in space or simulated by special ground-based devices provides an unusual
but unique environment to study and influence tumour cell processes. By investigating …

Testing Lab-on-a-Chip technology for culturing human melanoma cells under simulated microgravity

D Przystupski, A Górska, O Michel, A Podwin… - Cancers, 2021 - mdpi.com
Simple Summary The main aim of this study was to investigate whether all-glass Lab-on-a-
Chip (LOC) platforms can be applied to cancer cell research performed under simulated …

Cancer studies under space conditions: Finding answers abroad

JL Cortés-Sánchez, J Callant, M Krüger, J Sahana… - Biomedicines, 2021 - mdpi.com
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …