Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

The postsynaptic density (PSD)-95 family of membrane-associated guanylate kinases
(MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitatory synapses …

Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception,
mood, and a host of cognitive processes. They are considered physiologically safe and do …

The tight junction protein ZO-1 belongs to a family of multidomain proteins known as the
membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been …

NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-
95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed …

Specific patterns of neuronal firing induce changes in synaptic strength that may contribute
to learning and memory. If the postsynaptic NMDA (N-methyl-d-aspartate) receptors are …

Shank is a recently described family of postsynaptic proteins that function as part of the
NMDA receptor–associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]) …

▪ Abstract PDZ domains are modular protein interaction domains that bind in a sequence-
specific fashion to short C-terminal peptides or internal peptides that fold in a β-finger. The …

PDZ domains are protein-protein recognition modules that play a central role in organizing
diverse cell signaling assemblies. These domains specifically recognize short C-terminal …