RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Abstract Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by
phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects …

Small molecules have been classically developed to inhibit enzyme activity; however, new
classes of small molecules that endow new functions to enzymes via proximity-mediated …

Protein phosphorylation is one of the most widely observed and important post-translational
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …

In recent years, with the successful development of proteolysis-targeting chimeric molecules
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most
prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer …

In response to environmental changes, signaling pathways rewire gene expression
programs through transcription factors. Epigenetic modification of the transcribed RNA can …

The utilization of proximity-mediated effects to perturb pathogenic proteins of interest (POIs)
has emerged as a powerful strategic alternative to conventional drug design approaches …

RNA structure and function are intimately tied to RNA binding protein recognition and
regulation. Posttranslational modifications are chemical modifications which can control …