Highlights•Therapeutic importance of ERK1/2, the ERK1/2 structures and the representative
ERK1/2 inhibitors are outlined.•The binding mechanism of ERK1/2 inhibitors with ERK1/2 is …

The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a
putative tumor suppressor spanning the common fragile site FRA16D, but as time has …

The common marmoset (Callithrix jacchus) has emerged as a valuable nonhuman primate
model in biomedical research with the recent release of high-quality reference genome …

Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by
neuronal loss and gliosis, with oligodendroglial cytoplasmic inclusions (GCIs) containing α …

Voxel-based morphometry provides an opportunity to study Alzheimer's disease (AD) at a
subtle level. Therefore, identifying the important brain voxels that can classify AD, early mild …

Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the
risk of developing Alzheimer's disease (AD) due to risk factors such as age, family history …

Diabetes has been associated with an increased risk of cognitive decline and dementia.
However, the mechanisms underlying this association remain unclear and no effective …

Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein
products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been …

Alzheimer's disease (AD) is an advanced and incurable neurodegenerative disease.
Genetic variations are intrinsic etiological factors contributing to the abnormal expression of …

Simple Summary WWOX encodes a protein whose deficiency severely impacts brain
development. Therefore, the impact of this tumor suppressor on brain tumors should also be …