Abstract In the United States, colorectal cancer (CRC) is the third most common and second
most lethal cancer. More than one-tenth of CRC cases (11% of colon cancers and 18% of …

Improvements in early detection, supportive care, and treatment have resulted in an
increasing number of cancer survivors, with a current 5-year relative survival rate for all …

Purpose To provide recommendations on prevention, screening, genetics, treatment, and
management for people at risk for hereditary colorectal cancer (CRC) syndromes. The …

Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …

2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …

Persons with the Lynch syndrome (LS) are at high risk for cancer, including cancers of the
small bowel, stomach, upper urologic tract (renal pelvis and ureter), ovary, biliary tract and …

Purpose Patients with Lynch syndrome are at high risk for colon and endometrial cancer, but
also at an elevated risk for other less common cancers. The purpose of this retrospective …

Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as
hereditary nonpolyposis colorectal cancer) has been well described, little is known about …

BACKGROUND & AIMS: Lynch syndrome is the most common hereditary colorectal cancer
(CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer …

BACKGROUND & AIMS: MUTYH-associated polyposis (MAP) is characterized by a lifetime
risk of colorectal cancer of up to 100%. However, no systematic evaluation of extracolonic …