Furin is the first discovered proprotein convertase member and is present in almost all
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …

Discovered in 1996, PCSK7 is the seventh of the nine-membered proprotein convertase
subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted …

Ovarian cancer is the deadliest gynecological malignancy, and accounts for over 150,000
deaths per year worldwide. The high grade serous ovarian carcinoma (HGSC) subtype …

The hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the
endocytosis/lysosomal degradation of desialylated glycoproteins following binding to …

Several elements have an impact on COVID-19, including comorbidities, age and sex. To
determine the protein profile changes in peripheral blood caused by a SARS-CoV-2 …

A significant portion of mammalian proteomes is secreted to the extracellular space to fulfill
crucial roles in cell-to-cell communication. To best recapitulate the intricate and multi-faceted …

Breast cancer is one of the most serious and deadly cancers in women worldwide, with
distant metastases being the leading cause of death. Tn antigen, a tumor‐associated …

Objectives Thyroid cancer is the most common endocrine tumor, with rapidly increasing
incidence worldwide. However, its transcriptomic characteristics associated with …

The extracellular matrix (ECM) serves as a physical scaffold for tissues that is composed of
structural proteins such as laminins, collagens, proteoglycans and fibronectin, forming a …

The regulatory mechanism of PCSK7 gene is still unknown, although its encoded protein
PC7 is the most ancient and highly conserved of all proprotein convertases and exhibits …