Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: Advantages and limitations

Y Zorkina, O Abramova, V Ushakova, A Morozova… - Molecules, 2020 - mdpi.com
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

Applications of innovative technologies to the delivery of antipsychotics

MC Bergonzi, AR Bilia, E Landucci - Drug Discovery Today, 2022 - Elsevier
Psychosis is a high-incidence pathology associated with a profound alteration in the
perception of reality. The limitations of drugs available on the market have stimulated the …

Preparation and evaluation of the anti-cancer properties of RGD-modified curcumin-loaded chitosan/perfluorohexane nanocapsules in vitro

L Wang, S Zhu, C Zou, H Kou, M Xu, J Li - Heliyon, 2022 - cell.com
Curcumin (Cur) encapsulation in nanocapsules (NCs) could improve its availability and
therapeutic antitumor efficacy. Cur-loaded chitosan/perfluorohexane (CS/PFH) …

Evaluating non-conventional chitosan sources for controlled release of risperidone

S Garcinuño, I Aranaz, C Civera, C Arias, N Acosta - Polymers, 2022 - mdpi.com
In this work, two chitosan samples from cuttlebone and squid pen are produced and
characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol …

[HTML][HTML] To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges

AC Wehn, E Krestel, BN Harapan… - Journal of Controlled …, 2024 - Elsevier
Nanoparticles have a great potential to significantly improve the delivery of therapeutics to
the brain and may also be equipped with properties to investigate brain function. The brain …

Tumor-targeted fluorescent proteinoid nanocapsules encapsulating synergistic drugs for personalized cancer therapy

E Itzhaki, E Hadad, N Moskovits, SM Stemmer… - Pharmaceuticals, 2021 - mdpi.com
Personalized cancer treatment based on specific mutations offers targeted therapy and is
preferred over “standard” chemotherapy. Proteinoid polymers produced by thermal step …

Tumor‐Targeted Poly (ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy–In Vivo Study

E Itzhaki, E Chausky‐Barzakh, A Atkins… - Advanced …, 2023 - Wiley Online Library
The arginine‐glycine‐glutamic acid (RGD) sequence, an αvβ3 integrin recognition site, is
overexpressed in malignancies and neovasculature, making it a potential therapeutic target …

Chirality of proteinoid nanoparticles made of lysine and phenylalanine

L Lugasi, G Otis, M Oliel, S Margel… - Polymers for Advanced …, 2022 - Wiley Online Library
Proteinoid nanoparticles composed of l‐lysine and l‐phenylalanine were prepared and
showed enantioselective adsorption of l‐amino acids at various pH values, emphasizing the …

Engineering of doxorubicin-encapsulating and TRAIL-conjugated poly (RGD) proteinoid nanocapsules for drug delivery applications

E Hadad, S Rudnick-Glick, E Itzhaki, MY Avivi… - Polymers, 2020 - mdpi.com
Proteinoids are non-toxic biodegradable polymers prepared by thermal step-growth
polymerization of amino acids. Here, P (RGD) proteinoids and proteinoid nanocapsules …

Heat of Dilution and Racemization of Chiral Amino Acid Solutions

M Oliel, Y Mastai - Journal of Solution Chemistry, 2024 - Springer
Chiral interactions play a crucial role in both chemistry and biology. Understanding the
behavior of chiral molecules and their interactions with other molecules is essential, and …