Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

The cardiac benefits of exercise have been recognized for centuries. Studies have
undisputedly shown that regular exercise is beneficial for the cardiovascular system in …

Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in
experimental animal models have indicated the central role of mitochondria both in lifespan …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Aged mammalian tissues show a decreased capacity to produce ATP by oxidative
phosphorylation due to dysfunctional mitochondria. The mitochondrial content of rat brain …

Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative
damage and apoptosis are likely underlying factors. Autophagy, a process for the …

Acute exercise initiates rapid cellular signals, leading to the subsequent activation of
proteins that increase gene transcription. The result is a higher level of mRNA expression …