Chronic kidney disease (CKD) is a significant public health concern. Renal fibrosis is the
final common pathway in the progression of kidney diseases, irrespective of the initial injury …

Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is a slow but persistent
progression toward end-stage kidney disease. Earlier reports have shown that Hippo …

In this study, we investigated the impact of the uremic toxin indoxyl sulfate on macrophages
and tubular epithelial cells and its role in modulating the response to lipopolysaccharide …

Rupture or dissection of thoracic aortic aneurysms is still the leading cause of death for
patients diagnosed with Marfan syndrome. Inflammation and matrix digestion regulated by …

Prior research has established associations between immune cells, inflammatory proteins,
and chronic kidney disease (CKD). Our Mendelian randomization study aims to elucidate …

The absence of an effective imaging tool for diagnosing renal ischemia-reperfusion injury
(RIRI) severely delays its treatment, and currently, no definitive clinical interventions are …

Aging is a complex biological process that involves the gradual decline of cellular, tissue,
and organ functions. In kidney, aging manifests as tubular atrophy, glomerulosclerosis, and …

Background & Aims Hepatic fibrosis is characterized by enhanced deposition of extracellular
matrix (ECM), which results from the wound healing response to chronic, repeated injury of …

Mcpip1 is an endoribonuclease that targets proinflammatory transcripts. Our discoveries
prove that it inhibits hepatic stellate cell activation in both autocrine and paracrine manners …

Regnazą 1 jest cząsteczką o dowiedzionej roli antyzapalnej, za którą odpowiada aktywność
RNazowa i deubikwitynazowa tego białka. Molekularnym celem aktywności RNazowej …