Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …

Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells,
which are multipotent and possess the ability to differentiate/transdifferentiate into …

Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-
adenine-guanine expansion, which encodes a long glutamine tract (polyglutamine) in the …

Brain regenerative strategies through the transplantation of stem cells hold the potential to
promote functional rescue of brain lesions caused either by trauma or neurodegenerative …

Stem cells (SCs) are clonogenic cells that develop into the specialized cells which later
responsible for making up various types of tissue in the human body. SCs are not only the …

Background Stem cells(SC) functional heterogeneity and its poorly understood aetiology
impedes clinical development of cell-based therapies in regenerative medicine and …

Machado-Joseph disease (MJD) is a neurodegenerative disorder characterized by
widespread neuronal death affecting the cerebellum. Cell therapy can trigger neuronal …

Neurodegenerative diseases are characterized by extensive loss of function or death of
brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging …

Polyglutamine (polyQ) diseases are a group of neurodegenerative disorders involving
expanded CAG repeats in pathogenic genes that are translated into extended polyQ tracts …

Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-
adenine-guanine expansion, which encodes a long glutamine tract (polyglutamine) in the …