MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy

B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

MMPs in learning and memory and neuropsychiatric disorders

A Beroun, S Mitra, P Michaluk, B Pijet… - Cellular and Molecular …, 2019 - Springer
Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Thalamic regulation of sucrose seeking during unexpected reward omission

FH Do-Monte, A Minier-Toribio… - Neuron, 2017 - cell.com
The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral
responses under emotionally arousing conditions. Reward-associated cues activate PVT …

[HTML][HTML] IntelliCage as a tool for measuring mouse behavior–20 years perspective

A Kiryk, A Janusz, B Zglinicki, E Turkes… - Behavioural Brain …, 2020 - Elsevier
Since the 1980s, we have witnessed the rapid development of genetically modified mouse
models of human diseases. A large number of transgenic and knockout mice have been …

The BTBR mouse model of idiopathic autism–current view on mechanisms

KZ Meyza, DC Blanchard - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental
disorder, with current estimates of more than 1% of affected children across nations. The …

[HTML][HTML] Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights

VR Krishnaswamy, A Benbenishty, P Blinder… - Cellular and Molecular …, 2019 - Springer
The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

Progresses and prospects of neuroprotective agents-loaded nanoparticles and biomimetic material in ischemic stroke

J Chen, J Jin, K Li, L Shi, X Wen, F Fang - Frontiers in Cellular …, 2022 - frontiersin.org
Ischemic stroke remains the leading cause of death and disability, while the main
mechanisms of dominant neurological damage in stroke contain excitotoxicity, oxidative …

Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction

K Rojek-Sito, K Meyza, K Ziegart-Sadowska… - PLoS …, 2023 - journals.plos.org
For social interaction to be successful, two conditions must be met: the motivation to initiate it
and the ability to maintain it. This study uses both optogenetic and chemogenetic …

Matrix metalloproteinase 9 in epilepsy: the role of neuroinflammation in seizure development

E Bronisz… - Mediators of inflammation, 2016 - Wiley Online Library
Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often
studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart …

Transient ECM protease activity promotes synaptic plasticity

M Magnowska, T Gorkiewicz, A Suska… - Scientific reports, 2016 - nature.com
Activity-dependent proteolysis at a synapse has been recognized as a pivotal factor in
controlling dynamic changes in dendritic spine shape and function; however, excessive …