Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish
Xenograft cell transplantation into immunodeficient mice has become the gold standard for
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …
Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with
developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle …
developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle …
Rhabdomyosarcoma: current therapy, challenges, and future approaches to treatment strategies
Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …
muscle in children and young adults. It is responsible for 3% of all childhood malignant …
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
Signaling pathways in Rhabdomyosarcoma invasion and metastasis
Rhabdomyosarcoma (RMS) is an aggressive childhood mesenchymal tumor with two major
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
Modeling cancer with flies and fish
Cancer has joined heart disease as the leading source of mortality in the US. In an era of
organoids, patient-derived xenografts, and organs on a chip, model organisms continue to …
organoids, patient-derived xenografts, and organs on a chip, model organisms continue to …
Insights into pediatric rhabdomyosarcoma research: Challenges and goals
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
G Manzella, LD Schreck, WB Breunis… - Nature …, 2020 - nature.com
Cancer therapy is currently shifting from broadly used cytotoxic drugs to patient-specific
precision therapies. Druggable driver oncogenes, identified by molecular analyses, are …
precision therapies. Druggable driver oncogenes, identified by molecular analyses, are …