The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Background & Aims Little is known about the signaling pathways that initiate and promote
acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

The risks, measurements of severity, and management of severe acute pancreatitis and its
complications have evolved rapidly over the past decade. Evidence suggests that initial goal …

This paper reviews the current status of our understanding of the epidemiology, diagnosis,
and management of the continuum of pancreatic diseases from acute and recurrent acute …

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and
provokes stellate cell activation, with secretion of scar matrix. Conditions that augment …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

The precise mechanisms involved in the pathophysiology of acute pancreatitis (AP) are still
far from clear. Several earlier studies have focused mainly on pancreatic enzyme activation …

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most
prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer …