Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …

The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …

Historically the chemokine receptor CXCR4 and its canonical ligand CXCL12 are
associated with the bone marrow niche and hematopoiesis. However, CXCL12 exhibits …

Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging.
Soluble receptor-based strategies are not established for chemokine receptors due to their …

Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …

Neuropathic pain is a major, inadequately treated challenge for people with spinal cord
injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies …

Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …

Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a
high-affinity receptor for macrophage migration inhibitory factor (MIF), a pleiotropic cytokine …

Neuroinflammation is prevalent in multiple brain diseases and may also lead to dementia,
cognitive impairment, and impaired spatial memory function associated with …