Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

The basal ganglia are a series of interconnected subcortical nuclei. The function and
dysfunction of these nuclei have been studied intensively in motor control, but more recently …

Adaptive deep brain stimulation uses feedback about the state of neural circuits to control
stimulation rather than delivering fixed stimulation all the time, as currently performed. In …

Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for
advanced Parkinson's disease (PD) management. However, the mechanisms underlying …

Understanding the fundamental mechanisms governing fluctuating oscillations in large-
scale cortical circuits is a crucial prelude to a proper knowledge of their role in both adaptive …

This study compares the effects on motor symptoms between conventional deep brain
stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with …

Abnormal cortical oscillations are markers of Parkinson's Disease (PD). Transcranial
alternating current stimulation (tACS) can modulate brain oscillations and possibly impact on …

Functional neurosurgery has afforded the opportunity to assess interactions between
populations of neurons in the human cerebral cortex and basal ganglia in patients with …

Deep brain stimulation is a powerful clinical method for movement disorders that no longer
respond satisfactorily to pharmacological management, but its progress has been hampered …

Parkinson's disease (PD) is a heterogeneous disorder that leads to variable expression of
several different motor symptoms. While changes in firing rate, pattern, and oscillation of …