ERK1/2 MAP kinases: structure, function, and regulation
R Roskoski Jr - Pharmacological research, 2012 - Elsevier
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
Dual‐specificity MAP kinase phosphatases (MKPs) Shaping the outcome of MAP kinase signalling
Dual‐specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory
network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase …
network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase …
MAP kinase signalling cascades and transcriptional regulation
S Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2013 - Elsevier
The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of
cellular processes and are often deregulated in disease states. One major mode of action for …
cellular processes and are often deregulated in disease states. One major mode of action for …
[HTML][HTML] Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
JA McCubrey, LS Steelman, WH Chappell… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
Alternative splicing of MAPKs in the regulation of signaling specificity
The mitogen-activated protein kinase (MAPK) cascades transmit signals from extracellular
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …
The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target
The mitogen-activated protein kinase (MAPK) cascades are central signaling pathways that
play a central role in the regulation of most stimulated cellular processes including …
play a central role in the regulation of most stimulated cellular processes including …
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2
Serine/threonine/tyrosine-interacting protein (STYX) is a catalytically inactive member of the
dual-specificity phosphatases (DUSPs) family. Whereas the role of DUSPs in cellular …
dual-specificity phosphatases (DUSPs) family. Whereas the role of DUSPs in cellular …
Retention of ERK in the cytoplasm mediates the pluripotency of embryonic stem cells
AH Lev-Ran, R Seger - Stem cell reports, 2023 - cell.com
The dynamic subcellular localization of ERK1/2 plays an important role in regulating cell
fate. Differentiation of mouse embryonic stem cells (mESCs) involves inductive stimulation of …
fate. Differentiation of mouse embryonic stem cells (mESCs) involves inductive stimulation of …
Defined spatiotemporal features of RAS-ERK signals dictate cell fate in MCF-7 mammary epithelial cells
Signals conveyed through the RAS-ERK pathway are essential for the determination of cell
fate. It is well established that signal variability is achieved in the different …
fate. It is well established that signal variability is achieved in the different …
A novel role of alkaline phosphatase in the ERK1/2 dephosphorylation in renal cell carcinoma cell lines: a new plausible therapeutic target
U Sharma, D Pal, R Prasad - Biochimie, 2014 - Elsevier
Abstract Extracellular regulated kinase 1/2 (ERK1/2) has been shown to be activated in
renal cell carcinoma (RCC). Previously, we have reported aberrant expression/activity of …
renal cell carcinoma (RCC). Previously, we have reported aberrant expression/activity of …