Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders,
with around 30% of patients having a strong family history. The majority of that heritability is …

The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-
onset dementia. The diagnosis of bvFTD remains challenging because of the limited …

Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …

Background The tau positron emission tomography (PET) ligand 18 F-flortaucipir binds to
paired helical filaments of tau in aging and Alzheimer's disease (AD), but its utility in …

Sensitive and specific antemortem biomarkers of neurodegenerative disease and dementia
are crucial to the pursuit of effective treatments, required both to reliably identify disease and …

Frontotemporal dementia encompasses a group of clinical syndromes defined
pathologically by degeneration of the frontal and temporal lobes. Historically, these …

Developing and validating sensitive biomarkers for the presymptomatic stage of familial
frontotemporal dementia is an important step in early diagnosis and for the design of future …

Several CSF and blood biomarkers for genetic frontotemporal dementia have been
proposed, including those reflecting neuroaxonal loss (neurofilament light chain and …

Synaptic loss is an early and clinically relevant feature of many neurodegenerative
diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 …