Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …

Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Background Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake,
increases life span in many species. The implications for humans can be clarified by …

Discovering the biological basis of aging is one of the greatest remaining challenges for
science. Work on the biology of aging has discovered a range of interventions and pathways …

Numerous studies have highlighted the key roles of oxidative stress and inflammation in
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …

The laboratory mouse has become the predominant test species in biomedical research.
The number of papers that translate or extrapolate data from mouse to human has grown …

Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust
interventions known to increase longevity in lower organisms. However, little is known about …

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic
health in diverse species. However, whether DR in mammals is still effective when applied …