Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Breast cancer is the most common cancer and the most frequent cause of cancer death
among women worldwide. Breast cancer is a complex, heterogeneous disease classified …

Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron
overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as …

Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction
caused by a dysregulated host response to infection. Severe patients always present with …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to
treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether …

Cellular senescence is a form of cell cycle arrest that limits the proliferative potential of cells,
including tumour cells. However, inability of immune cells to subsequently eliminate …