Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases

H Aksnes, R Ree, T Arnesen - Molecular cell, 2019 - cell.com
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

Zipping and unzipping: protein modifications regulating synaptonemal complex dynamics

J Gao, MP Colaiácovo - Trends in Genetics, 2018 - cell.com
The proteinaceous zipper-like structure known as the synaptonemal complex (SC), which
forms between pairs of homologous chromosomes during meiosis from yeast to humans …

Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

CK Cahoon, CM Richter, AE Dayton, DE Libuda - Elife, 2023 - elifesciences.org
In sexually reproducing organisms, germ cells faithfully transmit the genome to the next
generation by forming haploid gametes, such as eggs and sperm. Although most meiotic …

Contribution of Agro-Environmental Factors to Yield and Plant Diversity of Olive Grove Ecosystems (Olea europaea L.) in the Mediterranean Landscape

AD Solomou, A Sfougaris - Agronomy, 2021 - mdpi.com
Olive cultivation (Olea europaea L.) is one of the most significant sources of income for
agricultural areas in the Mediterranean basin, and the olive oil industry as well as the …

Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation

A Sato-Carlton, C Nakamura-Tabuchi… - Journal of Cell …, 2018 - rupress.org
Chromosomes that have undergone crossing over in meiotic prophase must maintain sister
chromatid cohesion somewhere along their length between the first and second meiotic …

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

S Deng, B Pan, L Gottlieb, EJ Petersson… - Elife, 2020 - elifesciences.org
NatB is one of three major N-terminal acetyltransferase (NAT) complexes (NatA-NatC),
which co-translationally acetylate the N-termini of eukaryotic proteins. Its substrates account …

Multivalent weak interactions between assembly units drive synaptonemal complex formation

Z Zhang, S Xie, R Wang, S Guo, Q Zhao, H Nie… - Journal of Cell …, 2020 - rupress.org
The synaptonemal complex (SC) is an ordered but highly dynamic structure assembled
between homologous chromosomes to control interhomologous crossover formation …

Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis

SG Gordon, LE Kursel, K Xu, O Rog - PLoS genetics, 2021 - journals.plos.org
During sexual reproduction the parental homologous chromosomes find each other (pair)
and align along their lengths by integrating local sequence homology with large-scale …

[HTML][HTML] NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma

L Neri, M Lasa, A Elosegui-Artola, D D'Avola, B Carte… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The identification of new targets for systemic therapy of hepatocellular carcinoma (HCC) is
an urgent medical need. Recently, we showed that hNatB catalyzes the N-α-terminal …

The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans

R Wang, J Li, Y Tian, Y Sun, Y Zhang, M Liu… - Journal of Cell …, 2023 - rupress.org
During meiosis, cohesin and meiosis-specific proteins organize chromatin into an axis-loop
architecture, coordinating homologous synapsis, recombination, and ordered chromosome …