Virus-specific CD8+ T cells play an important role in controlling viral infections including
human immunodeficiency virus (HIV) infection. However, during chronic HIV infection, virus …

B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the
development and function of antibody-producing B cells. Given that its function in T …

Objective: In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched
in CD4+ T cells expressing immune checkpoint molecules, in particular programmed cell …

Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+ T
cells into T regulatory type 1 (TR1) cells, a subset of interleukin-10-producing Treg cells that …

T cell exhaustion represents one of the most pervasive strategies tumors employ to
circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as …

Cellular immune responses play a crucial role in the control of viral replication in HIV-
infected individuals. However, the virus succeeds in exploiting the immune system to its …

Tuberculosis (TB) and human immunodeficiency virus (HIV) infection interfere and impact
the pathogenesis phenomena of each other. Owing to atypical clinical presentations and …

Chronic HIV infection results in a loss of HIV-specific CD8+ T cell effector function, termed
“exhaustion,” which is mediated, in part, by the membrane coinhibitory receptor T cell …

Mild cognitive impairment (MCI) represents a cognitive state intermediate between normal
aging and early Alzheimer's disease (AD). To investigate if the molecular signature of MCI …

Migratory lung dendritic cells (DCs) transport viral antigen from the lungs to the draining
mediastinal lymph nodes (MLNs) during influenza virus infection to initiate the adaptive …