The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic
signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Our previous study using systems vaccinology identified an association between the sterol
regulatory binding protein (SREBP) pathway and humoral immune response to vaccination …

Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively)
are widely recognized as core components of stress granules (SGs). We report that G3BPs …

Background The intestine of children with severe malnutrition (SM) shows structural and
functional changes that are linked to increased infection and mortality. SM dysregulates the …

Virus infection leads to activation of the interferon (IFN)-induced endoribonuclease RNase L,
which results in degradation of viral and cellular RNAs. Both cellular and viral RNA cleavage …

The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-
related damage and promoting cell survival. SGs have become important players in human …

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a
particular function to cope with stress. These granules protect cells from stress-related …

Excess nutrient flux into the cellular energy system results in a scenario of cellular metabolic
stress in diseases involving insulin resistance, such as type 2 diabetes, referred to as nutri …

Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules,
processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological …