Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Acetyl-CoA, as an important molecule, not only participates in multiple intracellular
metabolic reactions, but also affects the post-translational modification of proteins, playing a …

Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human
body. The signaling functions of nitric oxide are accomplished through two primer …

Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular
milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which …

Simple Summary Glutamine (Gln) plays a critical role in the development and progression of
prostate cancer (PCa). Non-malignant prostate cells are not addicted to Gln, but PCa cells …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

Abstract Approximately 20–30% of human lung adenocarcinomas (LUADs) harbor
mutations in Kelch-like ECH-associated protein 1 (KEAP1) that hyperactivate the nuclear …

As a major cause of clinical chronic infection, microbial biofilms/microcolonies in host tissues
essentially live in 3D‐constrained microenvironments, which potentially modulate their …

The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on
health and is expected to have therapeutic value in neurological disorders, metabolic …

Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large
number of biochemical processes functioning either as an activator of molecules with …