Metastasis is a multi-step process that ultimately depends on the ability of disseminating
cancer cells to establish favorable communications with their microenvironment. The tumor …

The liver is a major metastasis-susceptible site and majority of patients with hepatic
metastasis die from the disease in the absence of efficient treatments. The intrahepatic …

Although angiogenesis is a prerequisite for the growth of most human solid tumours,
alternative mechanisms of vascularisation can be adopted. We have previously described a …

Myofibroblasts infiltrate malignant liver tumors, although their pathogenic implications are
unclear. Immunohistochemical detection of α-smooth muscle actin, glial fibrillary acidic …

Cancer-associated stromal fibroblasts (CAFs) are the main cellular constituents of reactive
stroma in primary and metastatic cancer. We analyzed phenotypical characteristics of CAFs …

Background The recruitment of vascular stromal and endothelial cells is an early event
occurring during cancer cell growth at premetastatic niches, but how the microenvironment …

Background The transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a
major mechanism for stroma development in hepatic metastasis, but their regulatory …

This review aims to give an update of the field of the hepatic sinusoid, supported by
references to presentations given at the 14th International Symposium on Cells of the …

The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis
in colorectal liver metastases from chemonaive patients with multiple liver metastases …

Anti-angiogenic therapy is a newly developed treatment method for malignant tumors.
Endostatin has an anti-angiogenetic effect. Endostatin has also been shown to block the …