Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis

C Slocum, C Kramer, CA Genco - Journal of internal medicine, 2016 - Wiley Online Library
Cardiovascular disease is an inflammatory disorder characterized by the progressive
formation of plaque in coronary arteries, termed atherosclerosis. It is a multifactorial disease …

PAMPs and DAMPs as the bridge between periodontitis and atherosclerosis: the potential therapeutic targets

X Zhu, H Huang, L Zhao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular
inflammation, eventually leading to myocardial infarction and stroke. Innate immunity plays …

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

S Poole, SK Singhrao, S Chukkapalli… - Journal of …, 2014 - journals.sagepub.com
Periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic
inflammation and direct infiltration of bacteria/bacterial components, which may contribute to …

Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis

IM Velsko, SS Chukkapalli, MF Rivera, JY Lee, H Chen… - PloS one, 2014 - journals.plos.org
Atherosclerotic vascular disease is a leading cause of myocardial infarction and
cerebrovascular accident, and independent associations with periodontal disease (PD) are …

Fusobacterium nucleatum Accelerates Atherosclerosis via Macrophage-Driven Aberrant Proinflammatory Response and Lipid Metabolism

J Zhou, L Liu, P Wu, L Zhao, Y Wu - Frontiers in Microbiology, 2022 - frontiersin.org
Periodontitis, an oral chronic inflammatory disease, is reported to show an association with
atherosclerotic vascular disease. Fusobacterium nucleatum is an oral commensal bacterium …

Interplay among the oral microbiome, oral cavity conditions, the host immune response, diabetes mellitus, and its associated-risk factors—An overview

TC Negrini, IZ Carlos, C Duque, KS Caiaffa… - Frontiers in oral …, 2021 - frontiersin.org
This comprehensive review of the literature aimed to investigate the interplay between the
oral microbiome, oral cavity conditions, and host immune response in Diabetes mellitus …

Linking mechanisms of periodontitis to Alzheimer's disease

M Sadrameli, P Bathini, L Alberi - Current opinion in neurology, 2020 - journals.lww.com
The pathogens of periodontal disease and the subsequent chronic inflammatory responses
have significant implications on the development of Alzheimer's disease. The exact …

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

DB Kell, E Pretorius - Biological Reviews, 2018 - Wiley Online Library
Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis

LJ Zhou, WZ Lin, XQ Meng, H Zhu, T Liu… - Cardiovascular …, 2023 - academic.oup.com
Aims Positive associations between periodontitis (PD) and atherosclerosis have been
established, but the causality and mechanisms are not clear. We aimed to explore the …

Neutrophil functions in periodontal homeostasis

R Cortés-Vieyra, C Rosales… - Journal of immunology …, 2016 - Wiley Online Library
Oral tissues are constantly exposed to damage from the mechanical effort of eating and to
microorganisms, mostly bacteria. In healthy gingiva tissue remodeling and a balance …