Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Background Besides featured glucose consumption, recent studies reveal that cancer cells
might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); …

Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …

Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Summary Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine,
is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its …

Alzheimer's disease (AD) is characterized as a distinct onset and progression of cognitive
and functional decline associated with age, as well as a specific neuropathology. It has been …