UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

The widespread use of neonicotinoid insecticides, such as imidacloprid, in agriculture is one
of the key factors for the drop in the survival of invertebrates, including decapod crustaceans …

Glucuronidation by uridine diphospho‐glucuronosyltransferase enzymes (UGTs) is a major
phase II biotransformation pathway and, complementary to phase I metabolism and …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

The purpose of this study was to generate, by real-time PCR, a quantitative expression level
profile of the 19 human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B …

The final therapeutic effect of a drug candidate, which is directed to a specific molecular
target strongly depends on its absorption, distribution, metabolism and excretion (ADME) …

Background UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of
enzymes. They catalyze the transfer of glycosyl residues from activated nucleotide sugars to …

Ten out of 19 UDP-glucuronosyltransferases (UGTs) are substantially expressed in adult
human liver (> 1% of total UGTs); 5 UGT1 isoforms (UGT1A1, 1A3, 1A4, 1A6 and 1A9) and 5 …

Serum bilirubin measurements are commonly obtained for the evaluation of ill patients and
to screen for liver disease in routine physical exams. An enormous research effort has …