Effectiveness of reinduction and/or dose escalation of ustekinumab in Crohn's disease: a systematic review and meta-analysis

J Meserve, C Ma, PS Dulai, V Jairath… - Clinical Gastroenterology …, 2022 - Elsevier
Background & Aims Patients with Crohn's disease (CD) treated with ustekinumab who
experience inadequate response, or loss of response after standard induction and/or …

Precision medicine and drug optimization in adult inflammatory bowel disease patients

S Vieujean, E Louis - Therapeutic Advances in …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD) encompass two main entities including ulcerative colitis
and Crohn's disease. Although having a common global pathophysiological mechanism …

The effectiveness of either ustekinumab or vedolizumab in 239 patients with Crohn's disease refractory to anti‐tumour necrosis factor

H Alric, A Amiot, J Kirchgesner, X Tréton… - Alimentary …, 2020 - Wiley Online Library
Background There is no head‐to‐head trial comparing ustekinumab and vedolizumab in
patients with Crohn's disease (CD) refractory to anti‐tumour necrosis factor (anti‐TNF). Aim …

Effectiveness and safety of ustekinumab intensification at 90 mg every 4 weeks in Crohn's disease: a multicentre study

M Fumery, L Peyrin-Biroulet, S Nancey… - Journal of Crohn's …, 2021 - academic.oup.com
Background The approved maintenance regimens for ustekinumab in Crohn's disease [CD]
are 90 mg every 8 or 12 weeks. Some patients will respond partially to ustekinumab or will …

The real-world effectiveness and safety of ustekinumab in the treatment of Crohn's disease: results from the SUCCESS consortium

AM Johnson, M Barsky, W Ahmed… - Official journal of the …, 2023 - journals.lww.com
METHODS: This study used a retrospective, multicenter, multinational consortium of UST-
treated CD patients. Data included patient demographics, disease phenotype, disease …

Korean clinical practice guidelines on biologics for moderate to severe Crohn's disease

SJ Koh, SN Hong, SK Park, BD Ye, KO Kim… - Intestinal …, 2022 - pmc.ncbi.nlm.nih.gov
Crohn's disease (CD) is a relapsing and progressive condition characterized by diarrhea,
abdominal pain, weight loss, and hematochezia that results in serious complications such as …

Predictors of ustekinumab failure in Crohn's disease after dose intensification

RS Dalal, C Njie, J Marcus, S Gupta… - Inflammatory Bowel …, 2021 - academic.oup.com
Abstract Background Many patients with Crohn's disease (CD) who lose response to the
standard ustekinumab dose interval of every 8 weeks (q8w) undergo dose intensification to …

[PDF][PDF] Predictors and outcomes of ustekinumab dose intensification in ulcerative colitis: a multicenter cohort study

RS Dalal, S Esckilsen, EL Barnes, JC Pruce… - Clinical …, 2022 - Elsevier
Study Design This retrospective cohort study included adults with UC (ICD-10-CM 51x)
initiating ustekinumab at Brigham and Women's Hospital, Massachusetts General Hospital …

Ustekinumab trough concentration affects clinical and endoscopic outcomes in patients with refractory Crohn's disease: a Chinese real-world study

J Yao, M Zhang, W Wang, X Peng, J Zhao, T Liu… - BMC …, 2021 - Springer
Background Ustekinumab (UST), a newly-used biologic targeting p40 subunit of IL12 and
IL23 in China, exerts a confirmed therapeutic effect on the induction and maintenance …

Dual biologic or small molecule therapy in refractory pediatric inflammatory bowel disease (DOUBLE-PIBD): a multicenter study from the pediatric IBD Porto Group of …

A Yerushalmy-Feler, C Olbjorn, KL Kolho… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Current data on dual biologic therapy in children are limited. This multicenter
study aimed to evaluate the effectiveness and safety of dual therapy in pediatric patients with …