Drug delivery technologies represent a vast and vital area of Research and Development.
The demand for innovative drug delivery systems continues to grow, and this growth …

The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA),
frequently causes drug-resistance and some adverse effects. Thus, an effective and safe …

The effective delivery of menahydroquinone-4 (MKH), an active form of menaquinone-4 (MK-
4, vitamin K2 (20)), to the skin is beneficial in the treatment of various skin pathologies …

Reduced cellular uptake of menaquinone-4 (MK-4), a vitamin K2 homolog, in human
hepatocellular carcinoma (HCC) limits its usefulness as a safe long-term antitumor agent for …

Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent
recurrence even after curative treatment. Thus, an effective and safe long-term …

d-γ-Tocopherol (γ-T230) and its major metabolite, 2, 7, 8-trimethyl-2S-(β-carboxyethyl)-6-
hydroxychroman (S-γ-CEHC), are currently receiving attention concerning their unique …

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of
ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high …

The intestinal absorption of hydrophobic compounds is severely influenced by their
transportation rate through the unstirred water layer in the intestinal lumen. A member of the …

抄録 The N, N-dimethylglycine esters of menahydroquinone-4 (1-mono, 1; 4-mono, 2; 1, 4-
bis, 3) were established in previous reports as prodrugs that could achieve the systemic …

The novel role of oxidants and antioxidants as part of cell signaling cascades has opened
new areas of research in several disease states and their therapeutic strategies. For …