Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …

A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …

Process modeling is gaining attention in the pharmaceutical industry due to the promise of
exploring the design space with less experimentation. However, the associated numerical …

Computational predictions of the polymorphic outcomes of a crystallization process, referred
to as polymorph selection, can accelerate the process development for manufacturing solid …

This study introduces a novel machine learning-based digital design strategy for predicting
the final yield and particle size distribution (PSD) in cooling crystallization processes. The …

Developing a crystallization model that accurately predicts crystal growth and nucleation has
been an important topic in the pharmaceutical industry for the past few decades. Particularly …

Continuous crystallization provides advantages of producing solid products of consistent
quality attributes at a small equipment footprint. However, the intrinsic nucleation and growth …

Crystallization process control has attracted extensive research interest in recent years
within the field of industrial crystallization. This study focused on controlling the …

A mechanistic model is developed to study the formation of 2, 6-difluoropurine-9-THP from
starting material 2, 6-dichloropurine-9-THP. The 2, 6-difluoropurine-9-THP product is an …