Natural antioxidants have received tremendous attention over the last 3 decades. At the
same time, the attitude to free radicals is slowly changing, and their signalling role in …

Nature has selected osmolytes to protect intracellular macromolecules exposed to
denaturing conditions and stabilize proteins. Osmolytes are small naturally occurring …

The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often
limited by severe side effects and toxic sequelae. Regarding the mechanisms of these side …

Non-alcoholic fatty liver disease (NAFLD) is a condition in which excessive fat accumulates
in the liver of an individual who has not consumed excessive alcohol. Non-alcoholic …

Endurance athletes are susceptible to cellular damage initiated by excessive levels of
aerobic exercise-produced reactive oxygen species (ROS). Whilst ROS can contribute to the …

In hepatic toxicity induced in rats by two injections of thioacetamide (TAA, 350 mg/kg with an
interval of 8 hr), the action of quercetin was investigated. After 96 hr, TAA administration …

Abstract Background and Aim: Curcumin, the major polyphenolic compound in turmeric, has
been shown to attenuate hepatic damage in several animal models of liver injury. The aim of …

Reactive oxygen species (ROS) have been implicated in hepatic stellate cell activation and
liver fibrosis. We previously reported that α-lipoic acid (LA) and its reduced form …

The concept that taurine exhibits cytoprotective activity was introduced in 1981. Although
several studies at the time had supported the notion that taurine was capable of modulating …

A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN)
plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially …