Vascular disease is a progressive inflammatory condition fuelled by an unhealthy lifestyle of
physical inactivity, cholesterol-rich diet, and smoking. Together with endogenous factors …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

We observed previously that estrogen treatment increased the transcript levels of several
mitochondrial DNA (mtDNA)-encoded genes for mitochondrial respiratory chain (MRC) …

Estrogen replacement therapy has been associated with reduction of cardiovascular events
in postmenopausal women, though the mechanism for this benefit remains unclear. Here we …

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …

Estradiol (E) mediates increased synaptogenesis in the hippocampal CA1 stratum radiatum
(sr) and enhances memory in young and some aged female rats, depending on dose and …

In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects
including an increased incidence of thromboembolic events, classically attributed to an …

Impaired platelet-derived nitric oxide (NO) contributes to acute coronary syndromes by
enhancing platelet recruitment and thrombus formation. Polymorphic variants of the …

Estrogen sulfotransferase (EST, encoded by SULT1E1) catalyzes the sulfoconjugation and
inactivation of estrogens. Despite decades of biochemical study and the recognition that …

The employment studies of natural extracts in the prevention and treatment of several
diseases highlighted the role of different species of genus Ferula L., belonging to the …