Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

Neurotransmission is the electrical impulse-triggered propagation of signals between
neurons or between neurons and other cell types such as skeletal muscle cells. Recent …

Crosstalk between nerves and bone is essential for bone repair, for which Schwann cells
(SCs) are crucial in the regulation of the microenvironment. Considering that exosomes are …

Neurons of the peripheral nervous system retain the intrinsic capability of regenerate their
axons after injury, by triggering a complex activation response. This genetic switch is …

Peripheral nerve regeneration remains a significant clinical challenge due to the
unsatisfactory functional recovery and public health burden. Exosomes, especially those …

Peripheral nerve injury has a high incidence and often leads to severe losses of sensory
and motor functions in the afflicted limb. Autologous nerve grafts are widely accepted as the …

Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of
sensory or motor function in the areas in which injured and non-injured nerves come …