The review pinpoints operational concepts related to the redox biology network applied to
the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic …

The mitogen-activated protein kinase signaling pathway can be activated by a variety of
growth factors, cytokines, and hormones, and mediates numerous intracellular signals …

Oxidative stress is a common mechanism of liver injury. Recent investigations have
demonstrated that oxidant-induced liver injury is mediated by the direct effects of reactive …

Abstract p38 MAPKs are important mediators of signal transduction that respond to a wide
range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro …

The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular
oxidative stress that underlies a variety of forms of hepatocyte injury and death including that …

Oxidative stress has been implicated as the mechanism of hepatocyte injury from numerous
agents. Although reactive oxygen species injure cells by the modification of critical cellular …

Dasatinib, a multitargeted inhibitor of BCR–ABL and SRC kinases, exhibits antitumor activity
and extends the survival of patients with chronic myeloid leukemia (CML) and Philadelphia …

Although α-chaconine, one of the two major potato trisaccharide glycoalkaloids, have shown
cytotoxic effects on human cancer cells, the exact mechanism of this action of α-chaconine is …

Hypoxia‐ischemia with reperfusion is known to cause reactive oxygen species‐related
damage in mammalian systems, yet, the anoxia tolerant freshwater turtle is able to survive …

Mdm2 inactivates the tumor suppressor p53 and Akt has been shown to be a major activator
of Mdm2 in many cell types. We have investigated the regulation of Mdm2 in hepatocytes …