Potassium disorders are common in patients with kidney disease, particularly in patients
with tubular disorders and low glomerular filtration rate. A multidisciplinary group of …

In the majority of cases, there is no difficulty in diagnosing Cystic Fibrosis (CF). However,
there may be wide variation in signs and symptoms between individuals which encourage …

The large-conductance voltage and calcium-sensitive BK channel is important in many
electrically active cells. Its unique sensitivity to both intracellular calcium levels and …

Studies in human colonic cell lines and murine intestine suggest the presence of a Ca2+-
activated anion channel, presumably TMEM16a. Is there a potential for fluid secretion in …

Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …

Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR
regulates the membrane physical state, microdomain formation and the activity of membrane …

Key points Submucosal neurons are crucial regulators of gut secretion. Despite significant
interest in using mouse models for enteric neuropathies, much is still unknown about their …

The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining
K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag …

Several potassium channels (KCs) have been described throughout the gastrointestinal
tract. Notwithstanding, their contribution to both physiologic and pathophysiologic …

The loop diuretic furosemide inhibits NaCl reabsorption in the thick ascending limb (TAL). In
addition, furosemide acidifies the urine, which is traditionally explained by increased Na+ …