Plant-associated endophytes define an important symbiotic association in nature and are
established bio-reservoirs of plant-derived natural products. Endophytes colonize the …

Ethnopharmacological relevance Chemotherapy is a common cancer treatment strategy.
However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae …

Microbial endophytes are ubiquitous and exist in each recognised plant species reported till
date. Within the host plant, the entire community of microbes lives non-invasively within the …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

Abstract Camptothecin (CPT), a well-known natural anti-cancer drug, is produced from
woody plant Camptotheca acuminata. Up to now, two CPT-derivatives, irinotecan and …

Endophytes, being the co-evolution partners of green host plants, are factories of
pharmaceutically valuable novel natural products. Cochliobolus sp. APS1, an endophyte of …

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries for the
treatment and management of various diseases. However, their effective delivery to targeted …

A series of near-infrared fluorescent probes, labeled A to E, were developed by combining
electron-rich thiophene and 3, 4-ethylenedioxythiophene bridges with 3-quinolinium and …

Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …

Background Electrospinning has provided an excellent opportunity to develop nano-sized
fibers with a broad range of applications, including nano-drug delivery systems for the …