▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene
expression plays a crucial role in the control of the immune response. A major breakthrough …

Plasma cells are terminally differentiated final effectors of the humoral immune response.
Plasma cells that result from antigen activation of B-1 and marginal zone B cells provide the …

Multiple myeloma (MM) remains an incurable disease, with a treatment-refractory state
eventually developing in all patients. Constant clonal evolution and genetic heterogeneity of …

Class II transactivator (CIITA), a coactivator required for class II major histocompatibility
complex (MHC) transcription, is expressed in B cells but extinguished in plasma cells. This …

Human nucleotide-binding oligomerization domain (NOD)-like receptors (NLR) include a
large family of proteins that have important functions in basic physio-pathological processes …

Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-
binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP …

The regulation of MHC class II gene expression controls T-cell activation and, hence, the
immune response. Among the nuclear factors observed to bind to conserved DNA …

Abstract Purpose: Cyclin B2, a G2-M cyclin, is overexpressed in colorectal adenocarcinomas
compared with the normal mucosa. This study examined the level of cyclin B2 …

Constitutive major histocompatibility complex (MHC) class II gene expression is tightly
restricted to antigen presenting cells and is under developmental control. Cells of the B cell …

Secondary lymphoid tissue and immunoglobulin (Ig) production in mammals is not fully
developed at birth, requiring time postnatally to attain all features required for adaptive …