The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be
molecularly defined. RB1 mutations occur in almost all familial and sporadic forms of …

Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Retinoblastoma is a childhood retinal tumour that initiates in response to biallelic RB1
inactivation and loss of functional retinoblastoma (Rb) protein. Although Rb has diverse …

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as
humans, plants, and insects. These proteins play a key role in regulating advancement of …

Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has
been regarded as a prototype tumor suppressor gene providing a paradigm for tumor …

With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of
intraocular tumour found to affect patients during their early childhood. It is curable if …

Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous
inactivation of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to …