A key parameter in the design of new active compounds is lipophilicity, which influences the
solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic …

In metabolomics, retention prediction methods have been developed based on the structural
and physicochemical characteristics of analytes. Such methods employ regression models …

For more than a century, chromatography has been indispensable as a separation method
for both analytics and purification. Among the variety of chromatographic techniques, liquid …

Lipophilicity in addition to the solubility, acid-base character and stability is one of the most
important physicochemical parameters of a compound required to assess the ADMET …

The predictive modeling of liquid chromatography methods can be an invaluable asset,
potentially saving countless hours of labor while also reducing solvent consumption and …

Naturally occurring molecules are excellent sources of lead compounds. A series of
oleanolic acid (OA) derivatives previously synthesized in our laboratory, which show …

Lipophilicity is one of the basic properties of a potential drug determining its solubility in non-
polar solvents and, consequently, its ability to passively penetrate the cell membrane, as …

Capillary electrophoresis (CE) is an analytical technique widely applied in clinical, industrial,
and scientific laboratories. Discussion of scientists' and specialists' concerns regarding the …

Passive permeability is one of the key features that determine absorbability and one of the
most studied properties in the early phases of drug development. Newly synthesized …

The development of screening methods for the estimation of physicochemical, biological
and pharmacokinetic properties of new pharmaceutical agents at early stage of the drug …