Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

Toxoplasmosis is a worldwide parasitic disease infecting about one third of humans, with
possible severe outcomes in neonates and immunocompromised patients. Despite …

Aims Cytokines, soluble mediators of immunity, are key factors of the innate and adaptive
immune system. They are secreted from and interact with various types of immune cells to …

Transpresentation has emerged as an important mechanism mediating IL-15 responses in a
subset of lymphocytes during the steady state. In transpresentation, cell surface IL-15, bound …

We reported earlier that during chronic toxoplasmosis CD8+ T cells become functionally
exhausted with concomitant PD-1 upregulation, leading to eventual host mortality. However …

Toxoplasma gondii is the protozoan causative agent of toxoplasmosis in humans and warm-
blooded animals. Recent studies have illustrated that the immune system plays a pivotal role …

The synergistic protective efficacy of murine interleukin 21 (mIL-21) and mIL-15
administrated with DNA vaccine against acute and chronic Toxoplasma gondii infection in …

We previously demonstrated that brain-resident cells produce IFN-γ in response to
reactivation of cerebral infection with Toxoplasma gondii. To obtain an overall landscape …

Background Toxoplasma gondii is an obligate intracellular parasite that can infect almost all
warm-blooded animals. T. gondii profilin (TgPF) plays a crucial role in parasite motility and …

CD8 T cells are essential for control of Toxoplasma gondii infection. Once activated they
undergo differentiation into short‐lived effector and memory precursor effector cells. As …