The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site)
signaling pathways have been conserved throughout evolution. Appropriately regulated …

Wnt signaling regulates a variety of cellular processes during embryonic development and
in the adult. Many of these activities are mediated by the Frizzled family of seven-pass …

A complex regulatory network of morphogens and transcription factors is essential for
normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac …

The canonical Wnt/β-catenin pathway is activated in triple-negative breast cancer (TNBC).
The activation of this pathway leads to the expression of specific target genes depending on …

Spondin-2 (SPON2), also referred to as M-spondin or DIL-1, is a member of the extracellular
matrix protein family known as Mindin-F-spondin (FS). SPON2 can be used as a broad …

Dishevelled (Dvl) proteins are intracellular effectors of Wnt signaling that have essential
roles in both canonical and noncanonical Wnt pathways. It has long been known that Wnts …

The characterization of mammary stem cells, and signals that regulate their behavior, is of
central importance in understanding developmental changes in the mammary gland and …

Microarray profiling was used to investigate gene expression in the hypoxic seizure model of
acquired epilepsy in the rat, with the aim of characterizing functional pathways which are …

DNA methylation changes are known to occur in gastric cancers and in premalignant lesions
of the gastric mucosae. In order to examine variables associated with methylation levels, we …

Background Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the
Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a …