Mucosal immunity in COVID-19: a neglected but critical aspect of SARS-CoV-2 infection

MW Russell, Z Moldoveanu, PL Ogra… - Frontiers in …, 2020 - frontiersin.org
The mucosal immune system is the largest component of the entire immune system, having
evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS …

COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

FJ Ryan, CM Hope, MG Masavuli, MA Lynn… - BMC medicine, 2022 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …

[HTML][HTML] Human IgG and IgA responses to COVID-19 mRNA vaccines

AV Wisnewski, JC Luna, CA Redlich - PloS one, 2021 - journals.plos.org
SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral
neutralization and are likely an important component of natural immunity, however, limited …

Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

SP Anand, J Prévost, M Nayrac… - Cell Reports …, 2021 - cell.com
With the recent approval of highly effective coronavirus disease 2019 (COVID-19) vaccines,
functional and lasting immunity to severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans

K Vanshylla, V Di Cristanziano, F Kleipass, F Dewald… - Cell host & …, 2021 - cell.com
Understanding antibody-based SARS-CoV-2 immunity is critical for overcoming the COVID-
19 pandemic and informing vaccination strategies. We evaluated SARS-CoV-2 antibody …

Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sources

DJ Sullivan, M Franchini, MJ Joyner… - Nature …, 2022 - nature.com
The latest SARS-CoV-2 variant of concern Omicron, with its immune escape from
therapeutic anti-Spike monoclonal antibodies and WA-1 vaccine-elicited sera, demonstrates …

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome

I Sulaiman, M Chung, L Angel, JCJ Tsay, BG Wu… - Nature …, 2021 - nature.com
Respiratory failure is associated with increased mortality in COVID-19 patients. There are no
validated lower airway biomarkers to predict clinical outcome. We investigated whether …

Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

Robust antibody levels in both diabetic and non-diabetic individuals after BNT162b2 mRNA COVID-19 vaccination

H Ali, A Alterki, S Sindhu, B Alahmad… - Frontiers in …, 2021 - frontiersin.org
The emergence of effective vaccines for COVID-19 has been welcomed by the world with
great optimism. Given their increased susceptibility to COVID-19, the question arises …