The diversity and functions of plant RNA modifications: what we know and where we go from here

B Sharma, W Prall, G Bhatia… - Annual Review of Plant …, 2023 - annualreviews.org
Since the discovery of the first ribonucleic acid (RNA) modifications in transfer RNAs (tRNAs)
and ribosomal RNAs (rRNAs), scientists have been on a quest to decipher the identities and …

N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection

T Zhang, C Shi, H Hu, Z Zhang, Z Wang, Z Chen… - Nature …, 2022 - nature.com
Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes
has been adopted as an alternative strategy for controlling crop diseases. Here, we show …

Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus

M Martínez‐Pérez, F Aparicio… - The EMBO …, 2023 - embopress.org
In virus–host interactions, nucleic acid‐directed first lines of defense that allow viral
clearance without compromising growth are of paramount importance. Plants use the RNA …

m6A RNA demethylase AtALKBH9B promotes mobilization of a heat-activated long terminal repeat retrotransposon in Arabidopsis

W Fan, L Wang, Z Lei, H Li, J Chu, M Yan, Y Wang… - Science …, 2023 - science.org
Transposons are mobile and ubiquitous DNA molecules that can cause vast genomic
alterations. In plants, it is well documented that transposon mobilization is strongly …

The Roles of N6-Methyladenosine Modification in Plant–RNA Virus Interactions

M He, Z Li, X Xie - International Journal of Molecular Sciences, 2023 - mdpi.com
N6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification. Recently, its
role in viruses has led to the study of viral epitranscriptomics. m6A has been observed in …

Pathogen-induced m6A dynamics affect plant immunity

W Prall, AH Sheikh, J Bazin, J Bigeard… - The Plant …, 2023 - academic.oup.com
Posttranscriptional regulation of mRNA mediated by methylation at the N6 position of
adenine (N6-methyladenosine [m6A]) has profound effects on transcriptome regulation in …

The m6A RNA Demethylase ALKBH9B Plays a Critical Role for Vascular Movement of Alfalfa Mosaic Virus in Arabidopsis

M Martínez-Pérez, C Gómez-Mena… - Frontiers in …, 2021 - frontiersin.org
The N 6-methyladenosine (m6A) pathway has been widely described as a viral regulatory
mechanism in animals. We previously reported that the capsid protein (CP) of alfalfa mosaic …

m6A RNA methylation impairs gene expression variability and reproductive thermotolerance in Arabidopsis

L Wang, H Zhuang, W Fan, X Zhang, H Dong, H Yang… - Genome Biology, 2022 - Springer
Heat-imposed crop failure is often attributed to reduced thermotolerance of floral tissues;
however, the underlying mechanism remains unknown. Here, we demonstrate that m6A …

AlkB RNA demethylase homologues and N6‐methyladenosine are involved in Potyvirus infection

J Yue, Y Wei, Z Sun, Y Chen, X Wei… - Molecular plant …, 2022 - Wiley Online Library
Proteins of the alkylation B (AlkB) superfamily show RNA demethylase activity removing
methyl adducts from N 6‐methyladenosine (m6A). m6A is a reversible epigenetic mark of …

Impact of the Potential m6A Modification Sites at the 3′UTR of Alfalfa Mosaic Virus RNA3 in the Viral Infection

L Alvarado-Marchena, M Martínez-Pérez, JR Úbeda… - Viruses, 2022 - mdpi.com
We have previously reported the presence of m6A in the AMV (Alfamovirus, Bromoviridae)
genome. Interestingly, two of these putative m6A-sites are in hairpin (hp) structures in the …