Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Real-time fluorescence imaging in intraoperative decision making for cancer surgery

LJ Lauwerends, PBAA van Driel, RJB de Jong… - The Lancet …, 2021 - thelancet.com
Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

Determination of tumor margins with surgical specimen mapping using near-infrared fluorescence

RW Gao, NT Teraphongphom, NS van den Berg… - Cancer research, 2018 - AACR
For many solid tumors, surgical resection remains the gold standard and tumor-involved
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …

Illuminating the future of precision cancer surgery with fluorescence imaging and artificial intelligence convergence

H Cheng, H Xu, B Peng, X Huang, Y Hu… - NPJ Precision …, 2024 - nature.com
Real-time and accurate guidance for tumor resection has long been anticipated by
surgeons. In the past decade, the flourishing material science has made impressive …

The clinical application of fluorescence-guided surgery in head and neck cancer

S van Keulen, N Nishio, S Fakurnejad… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Although surgical resection has been the primary treatment modality of solid tumors for
decades, surgeons still rely on visual cues and palpation to delineate healthy from …

Surgical margins in oral cavity squamous cell carcinoma: current practices and future directions

JJ Kain, AC Birkeland, N Udayakumar… - The …, 2020 - Wiley Online Library
Objective To discuss the current available techniques for intraoperative margin assessment
in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the …

Emerging intraoperative imaging modalities to improve surgical precision

IS Alam, I Steinberg, O Vermesh… - Molecular Imaging and …, 2018 - Springer
Intraoperative imaging (IOI) is performed to guide delineation and localization of regions of
surgical interest. While oncological surgical planning predominantly utilizes x-ray computed …

Quantifying the impact of signal-to-background ratios on surgical discrimination of fluorescent lesions

S Azargoshasb, I Boekestijn, M Roestenberg… - Molecular Imaging and …, 2023 - Springer
Purpose Surgical fluorescence guidance has gained popularity in various settings, eg,
minimally invasive robot-assisted laparoscopic surgery. In pursuit of novel receptor-targeted …

Fluorescence guidance in surgical oncology: challenges, opportunities, and translation

MT Olson, QP Ly, AM Mohs - Molecular imaging and biology, 2019 - Springer
Surgical resection continues to function as the primary treatment option for most solid
tumors. However, the detection of cancerous tissue remains predominantly subjective and …

Current intraoperative imaging techniques to improve surgical resection of laryngeal cancer: a systematic review

LJ Lauwerends, HA Galema, JAU Hardillo, A Sewnaik… - Cancers, 2021 - mdpi.com
Simple Summary Laryngeal cancer is a prevalent head and neck malignancy, with poor
prognosis and low survival rates for patients with advanced disease. The recurrence rate for …