Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Marching into the second decade after the approval of ipilimumab, it is clear that immune
checkpoint inhibitors (ICIs) have dramatically improved the prognosis of melanoma …

Extracellular vesicles (EVs) carrying tumor cell-derived programmed death-ligand 1 (PD-L1)
interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a …

Metastasis and immune suppression account for the poor prognosis of oral squamous cell
carcinoma (OSCC). YKT6 is a member of the soluble NSF attachment protein receptor …

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Methods We used single-cell transcriptome sequencing and multiplex
immunohistochemistry to investigate the immune microenvironment of EGFR-mutant and …

Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment.
Despite demonstrable progress, most patients fail to respond or achieve durable responses …

Immune checkpoint blockade (ICB) therapies exhibit substantial clinical benefit in different
cancers, but relatively low response rates in the majority of patients highlight the need to …

The importance of the early diagnosis and treatment of diabetes and its cutaneous
complications has become increasingly recognized. When diabetic non-injured skin was …